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The routine use of dipyridamole in secondary prevention after cerebrovascular events has been controversial.
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Dipyridamole moderate because dipyridamole is a platelet inhibitor, there is a potential additive risk for bleeding if dipyridamole is given in combination with other agents that affect hemostasis.
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2 considerable discussion, largely based on the results of esps ii, has focused on whether dipyridamole has selective effects on stroke.
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When state-of-the-art protocols are used for both stresses 3639 , the sensitivity, specificity, and accuracy of fast or atropine-potentiated high-dose dipyridamole are identical to dobutamine stress echocardiography, as shown by a meta-analysis including five studies with 435 patients fig.
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In esps2 patients see clinical studies 14 , with creatinine clearances ranging from about 15 ml min to 100 ml min, no changes were observed in the pharmacokinetics of dipyridamole or its glucuronide metabolite if data were corrected for differences in age.
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